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Germany offers a diverse and welcoming ecosystem for researchers and innovators from across the world. From the maritime North to the Alps in the South: Our short film takes you on a journey to "Research Wonderland" Germany.

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Evolutionary trade-offs: Balancing genetic disease risks and pathogen protection

Evolutionary biologists from Kiel describe a novel way to identify previously unknown pathogens via disease genes

- Joint press release by Kiel University and the Max Planck Institute for Evolutionary Biology –Certain genes can exist in different, functionally divergent variants in the individuals of a species. If they lead to clear differences, for example in a phenotype or susceptibility to disease, this is known in biology as a polymorphism. Typical examples are a number of genes whose variants are responsible for the expression of different blood groups. Interestingly, these polymorphic genes can be relevant to blood groups and diseases at the same time. A research team from Kiel University and the Max Planck Institute for Evolutionary Biology (MPI-EB) led by Professor John Baines has now used mice as an example to investigate one such polymorphic gene, called B4galnt2, which in the individual animal can affect blood vessels and/or intestinal cells. In this new study, the researchers from the Section of Evolutionary Medicine at Kiel University and MPI-EB were able to show that depending on the variant, the gene can cause not only a blood coagulation disorder, but also better immunity to bacterial infections. The researchers, who are active in the Collaborative Research Center (CRC) 1182 "Origin and Function of Metaorganisms" and the Cluster of Excellence "Precision Medicine in Chronic Inflammation" (PMI), succeeded in demonstrating the involvement of an individual variant of B4galnt2 in the defence against pathogens by identifying a previously unknown bacterium from the genus Morganella. This group of microorganisms can cause problematic infections in humans, especially in hospitals and care facilities. In a so-called pathometagenomic analysis, the researchers showed that the prevalence of this bacterium relevant to inflammation is strongly restricted in mice with the B4galnt2 genotype affecting the blood vessels. They thus succeeded in elucidating an exemplary evolutionary trade-off between the risk for genetic disease and the evolutionary advantage of pathogen resistance that mice gain by retaining polymorphism at this gene. The researchers recently published their results in the scientific journal Gut Microbes. Balancing evolutionary trade-offsOver the course of evolution, certain genetic variants important for immune defence are favoured under the selective pressure of infectious diseases, and the corresponding variants are therefore maintained. Retaining such genes, however, is often linked to so-called evolutionary trade-offs: Mice are known for example to have kept alternative forms (i.e. alleles) of the blood group-related B4galnt2 gene for almost three million years, despite it causing a bleeding time phenotype similar to von Willebrand disease in humans, which causes prolonged bleeding after injury. "The maintenance of such a genetic variant must be associated with a strong selective advantage in other contexts, which were until now unknown," explains evolutionary biologist Baines. "Recent advances in the scientific understanding of the blood clotting system now suggest that genetic variation may also be involved in innate immunity and defence against pathogens, so we looked for a possible advantage of the B4galnt2 gene in this area," Baines continues. Pathometagenomic analysis shows links between genetic variation and pathogen protectionIn order to investigate the role of variation at B4galnt2 in possible immunity to pathogens, the Kiel research team chose a new, so-called pathometagenomic approach: The researchers first examined the intestinal tissue of the animals for signs of inflammation. In the next step, they identified the microorganisms present in the animals' intestine via genome sequencing to detect correlations between microbiome composition and signs of inflammation. "The overall composition of the microbiota does not seem to play a significant role at first. However, individual bacterial species were found to be disproportionately active in the presence of inflammation and particular genotypes at B4galnt2," summarises Baines. The researchers were able to narrow this observation to a previously unknown bacterial subspecies from the genus Morganella: Animals with the allele relevant for blood vessels and the associated risk for the blood clotting showed fewer signs of inflammation, with the bacterium almost being absent. In mice expressing B4galnt2 in the gastrointestinal tract, however, it is clearly detectable; the presence of inflammation here indicates its’ pathogenicity. "While these animals do not carry the risk of the bleeding phenotype, the expression of B4galnt2 in the intestinal mucosa can be favoured by pathogens. In the case of our analysis, it is Morganella that then leads to inflammation," says Baines. Novel way to identify still unknown pathogensIn order to validate their findings in wild mice, the Kiel researchers collaborated with the group of Professor Guntram Grassl, a medical microbiologist at Hannover Medical School. The researchers then validated these findings derived from wild animals with infection experiments using mice in the laboratory that differed only according to the alleles present at the B4galnt2 gene. When these animals were inoculated with the bacterium, they showed the same signs of disease as the wild animals. "This provides us with experimental evidence that the B4galnt2 gene plays an important role in susceptibility to bacterial infections in nature. This enabled us to validate that our novel pathometagenomic approach is in principle suitable for identifying yet unknown pathogens in wild animals, and thus for monitoring possible risks of such zoonotic pathogens for humans," says Grassl. With the work now presented, the Kiel research team was also able to provide further evidence for the longstanding hypothesis on the evolutionary origins of blood group systems in general: "An important pioneer of evolutionary biology, the British geneticist J. B. S. Haldane, foresaw as early as the middle of the 20th century that blood groups and pathogen resistance may be related to one another. With research into blood group-related genes, which are a particularly common target of natural selection, numerous examples of this were described more recently," says Baines. "However, the nature and extent of the evolutionary trade-offs involved are rarely explored in detail. With the help of our pathometagenomic analysis, we succeeded in linking pathogen resistance to a blood group-related gene, thus experimentally supporting Haldane's hypothesis," Baines continues.Scientific contact:Prof. John Baines, Research Group Evolutionary Genomics, Institute for Experimental Medicine, Kiel University/ Max-Planck-Institute for Evolutionary Biology+49 (0) 431-500-30310j.baines@iem.uni-kiel.de © Christian Urban, Kiel University Lead by Professor John Baines, the Kiel researchers found experimental evidence of the link between genetic disease risk and protection against infection.© Maryrose94 via Wikimedia Commons, CC BY-SA 4.0The expression of B4galnt2 in the intestinal mucosa can be favoured by various pathogens, which can lead to inflammation caused by, for example, a newly discovered subspecies of the bacterium Morganella morganii (pictured).Original publication:Marie Vallier, Abdulhadi Suwandi, Katrin Ehrhardt, Meriem Belheouane, David Berry, Aleksa Čepić, Alibek Galeev, Jill M. Johnsen, Guntram A. Grassl and John F. Baines (2023): Pathometagenomics reveals susceptibility to intestinal infection by Morganella to be mediated by the blood group-related B4galnt2 gene in wild mice. Gut Microbes First published: 22. January 2023 DOI: 10.1080/19490976.2022.2164448 More information:

About the CRC 1182:The Collaborative Research Centre "Origin and Function of Metaorganisms" is an interdisciplinary network involving around 80 researchers that investigates the interactions of specific microbial communities with multicellular host organisms. It is supported by the German Research Foundation (DFG) and deals with the question of how plants and animals including humans form functional units (metaorganisms) together with highly specific communities of microbes. The aim of the CRC 1182 is to understand why and how microbial communities enter into these long-term connections with their host organisms and what functional consequences these interactions have. The CRC 1182 brings together scientists from five faculties at Kiel University, the GEOMAR Helmholtz-Centre for Ocean Research Kiel, the Max-Planck-Institute for Evolutionary Biology Plön, the Heinrich-Heine-University Düsseldorf, the Leibniz Institute for Science and Mathematics Education and the Muthesius University of Fine Arts and Design.About Kiel Life Science (KLS)The interdisciplinary centre for applied life sciences – Kiel Life Science (KLS) – links research at the CAU from the fields of agricultural and nutritional sciences, the natural sciences and medicine. It forms one of four research focus areas at Kiel University, and is aimed at achieving a better understanding of the cellular and molecular processes with which organisms respond to environmental influences. The research is focussed on issues such as how agricultural crop plants adapt to specific growth conditions, or how illnesses can arise through the interaction of genes, individual lifestyle and environmental factors. Health is always viewed holistically in the context of evolution. Under the research focus’ name, there are currently around 80 scientists from 40 institutes and six faculties from Kiel University working collaboratively as full members.To Kiel Life Science (KLS)Press contact:Christian Urban Science communication „Kiel Life Science", Kiel University:+49 (0) 431-880-1974curban@uv.uni-kiel.de Related FilesThe expression of B4galnt2 in the intestinal mucosa can be favoured by various pathogens, which can lead to inflammation caused by, for example, a newly discovered subspecies of the bacterium Morganella morganii (pictured).

Evolutionary trade-offs: Balancing genetic disease risks and pathogen protection

Evolutionary biologists from Kiel describe a novel way to identify previously unknown pathogens via disease genes

- Joint press release by Kiel University and the Max Planck Institute for Evolutionary Biology –Certain genes can exist in different, functionally divergent variants in the individuals of a species. If they lead to clear differences, for example in a phenotype or susceptibility to disease, this is known in biology as a polymorphism. Typical examples are a number of genes whose variants are responsible for the expression of different blood groups. Interestingly, these polymorphic genes can be relevant to blood groups and diseases at the same time. A research team from Kiel University and the Max Planck Institute for Evolutionary Biology (MPI-EB) led by Professor John Baines has now used mice as an example to investigate one such polymorphic gene, called B4galnt2, which in the individual animal can affect blood vessels and/or intestinal cells. In this new study, the researchers from the Section of Evolutionary Medicine at Kiel University and MPI-EB were able to show that depending on the variant, the gene can cause not only a blood coagulation disorder, but also better immunity to bacterial infections. The researchers, who are active in the Collaborative Research Center (CRC) 1182 "Origin and Function of Metaorganisms" and the Cluster of Excellence "Precision Medicine in Chronic Inflammation" (PMI), succeeded in demonstrating the involvement of an individual variant of B4galnt2 in the defence against pathogens by identifying a previously unknown bacterium from the genus Morganella. This group of microorganisms can cause problematic infections in humans, especially in hospitals and care facilities. In a so-called pathometagenomic analysis, the researchers showed that the prevalence of this bacterium relevant to inflammation is strongly restricted in mice with the B4galnt2 genotype affecting the blood vessels. They thus succeeded in elucidating an exemplary evolutionary trade-off between the risk for genetic disease and the evolutionary advantage of pathogen resistance that mice gain by retaining polymorphism at this gene. The researchers recently published their results in the scientific journal Gut Microbes. Balancing evolutionary trade-offsOver the course of evolution, certain genetic variants important for immune defence are favoured under the selective pressure of infectious diseases, and the corresponding variants are therefore maintained. Retaining such genes, however, is often linked to so-called evolutionary trade-offs: Mice are known for example to have kept alternative forms (i.e. alleles) of the blood group-related B4galnt2 gene for almost three million years, despite it causing a bleeding time phenotype similar to von Willebrand disease in humans, which causes prolonged bleeding after injury. "The maintenance of such a genetic variant must be associated with a strong selective advantage in other contexts, which were until now unknown," explains evolutionary biologist Baines. "Recent advances in the scientific understanding of the blood clotting system now suggest that genetic variation may also be involved in innate immunity and defence against pathogens, so we looked for a possible advantage of the B4galnt2 gene in this area," Baines continues. Pathometagenomic analysis shows links between genetic variation and pathogen protectionIn order to investigate the role of variation at B4galnt2 in possible immunity to pathogens, the Kiel research team chose a new, so-called pathometagenomic approach: The researchers first examined the intestinal tissue of the animals for signs of inflammation. In the next step, they identified the microorganisms present in the animals' intestine via genome sequencing to detect correlations between microbiome composition and signs of inflammation. "The overall composition of the microbiota does not seem to play a significant role at first. However, individual bacterial species were found to be disproportionately active in the presence of inflammation and particular genotypes at B4galnt2," summarises Baines. The researchers were able to narrow this observation to a previously unknown bacterial subspecies from the genus Morganella: Animals with the allele relevant for blood vessels and the associated risk for the blood clotting showed fewer signs of inflammation, with the bacterium almost being absent. In mice expressing B4galnt2 in the gastrointestinal tract, however, it is clearly detectable; the presence of inflammation here indicates its’ pathogenicity. "While these animals do not carry the risk of the bleeding phenotype, the expression of B4galnt2 in the intestinal mucosa can be favoured by pathogens. In the case of our analysis, it is Morganella that then leads to inflammation," says Baines. Novel way to identify still unknown pathogensIn order to validate their findings in wild mice, the Kiel researchers collaborated with the group of Professor Guntram Grassl, a medical microbiologist at Hannover Medical School. The researchers then validated these findings derived from wild animals with infection experiments using mice in the laboratory that differed only according to the alleles present at the B4galnt2 gene. When these animals were inoculated with the bacterium, they showed the same signs of disease as the wild animals. "This provides us with experimental evidence that the B4galnt2 gene plays an important role in susceptibility to bacterial infections in nature. This enabled us to validate that our novel pathometagenomic approach is in principle suitable for identifying yet unknown pathogens in wild animals, and thus for monitoring possible risks of such zoonotic pathogens for humans," says Grassl. With the work now presented, the Kiel research team was also able to provide further evidence for the longstanding hypothesis on the evolutionary origins of blood group systems in general: "An important pioneer of evolutionary biology, the British geneticist J. B. S. Haldane, foresaw as early as the middle of the 20th century that blood groups and pathogen resistance may be related to one another. With research into blood group-related genes, which are a particularly common target of natural selection, numerous examples of this were described more recently," says Baines. "However, the nature and extent of the evolutionary trade-offs involved are rarely explored in detail. With the help of our pathometagenomic analysis, we succeeded in linking pathogen resistance to a blood group-related gene, thus experimentally supporting Haldane's hypothesis," Baines continues.Scientific contact:Prof. John Baines, Research Group Evolutionary Genomics, Institute for Experimental Medicine, Kiel University/ Max-Planck-Institute for Evolutionary Biology+49 (0) 431-500-30310j.baines@iem.uni-kiel.de © Christian Urban, Kiel University Lead by Professor John Baines, the Kiel researchers found experimental evidence of the link between genetic disease risk and protection against infection.© Maryrose94 via Wikimedia Commons, CC BY-SA 4.0The expression of B4galnt2 in the intestinal mucosa can be favoured by various pathogens, which can lead to inflammation caused by, for example, a newly discovered subspecies of the bacterium Morganella morganii (pictured).Original publication:Marie Vallier, Abdulhadi Suwandi, Katrin Ehrhardt, Meriem Belheouane, David Berry, Aleksa Čepić, Alibek Galeev, Jill M. Johnsen, Guntram A. Grassl and John F. Baines (2023): Pathometagenomics reveals susceptibility to intestinal infection by Morganella to be mediated by the blood group-related B4galnt2 gene in wild mice. Gut Microbes First published: 22. January 2023 DOI: 10.1080/19490976.2022.2164448 More information:

About the CRC 1182:The Collaborative Research Centre "Origin and Function of Metaorganisms" is an interdisciplinary network involving around 80 researchers that investigates the interactions of specific microbial communities with multicellular host organisms. It is supported by the German Research Foundation (DFG) and deals with the question of how plants and animals including humans form functional units (metaorganisms) together with highly specific communities of microbes. The aim of the CRC 1182 is to understand why and how microbial communities enter into these long-term connections with their host organisms and what functional consequences these interactions have. The CRC 1182 brings together scientists from five faculties at Kiel University, the GEOMAR Helmholtz-Centre for Ocean Research Kiel, the Max-Planck-Institute for Evolutionary Biology Plön, the Heinrich-Heine-University Düsseldorf, the Leibniz Institute for Science and Mathematics Education and the Muthesius University of Fine Arts and Design.About Kiel Life Science (KLS)The interdisciplinary centre for applied life sciences – Kiel Life Science (KLS) – links research at the CAU from the fields of agricultural and nutritional sciences, the natural sciences and medicine. It forms one of four research focus areas at Kiel University, and is aimed at achieving a better understanding of the cellular and molecular processes with which organisms respond to environmental influences. The research is focussed on issues such as how agricultural crop plants adapt to specific growth conditions, or how illnesses can arise through the interaction of genes, individual lifestyle and environmental factors. Health is always viewed holistically in the context of evolution. Under the research focus’ name, there are currently around 80 scientists from 40 institutes and six faculties from Kiel University working collaboratively as full members.To Kiel Life Science (KLS)Press contact:Christian Urban Science communication „Kiel Life Science", Kiel University:+49 (0) 431-880-1974curban@uv.uni-kiel.de Related FilesThe expression of B4galnt2 in the intestinal mucosa can be favoured by various pathogens, which can lead to inflammation caused by, for example, a newly discovered subspecies of the bacterium Morganella morganii (pictured).